DISCOTRINTrinitrin in patch form at 5 mg for 24 hours, 10 mg for 24 hours and 15 mg for 24 hours.Action
Nitroglycerin has vasodilatory properties that primarily affect the veins. In other words, this molecule increases the caliber of the vessels. It also has a relaxing effect on the muscles that make up the vessels, leading to a reduction in pressure inside the heart, and consequently a reduction in cardiac workload and a redistribution of coronary circulation to the failing (ischemic) cardiac areas.
Nitroglycerin, at higher doses, causes a slight opening of the caliber of the arteries with a drop in blood pressure.
If you want to achieve almost immediate action, you can use the sublingual route (under the tongue). However, this method should be short-term (approximately 1 hour).
The percutaneous route (through the skin) can also be used, requiring higher doses but allowing for a longer and more regular action, especially for forms with a prolonged action.
Indications
The indications are directly dependent on the dosage form used (tablets, capsules, injectable, spray, ointment, adhesive patch)
Trinitrin is used for:
· Prevention and treatment of angina attacks
· Acute pulmonary edema in addition to other usual therapies
· The prolonged trinitrin form is particularly useful in the preventive treatment of angina attacks and in the adjuvant treatment of subacute left heart failure.
· The injectable form is used for severe angina pectoris and for heart failure, especially in the acute phase of myocardial infarction, as well as for acute pulmonary edema.
· The transcutaneous form with its transdermal patch and ointment device is used in the preventive treatment of angina attacks.
Dosage
1 system per day.
Contraindications
They are not described.
Precautions for use
Nitroglycerin-based treatment should never be stopped abruptly, especially if it is prolonged and at a high dose.
The effective dosage should be reached gradually. Indeed, there is a risk of hypertension and severe headaches in some patients. In patients with obstructive cardiomyopathy, nitroglycerin should be avoided.
In cases of circulatory insufficiency causing cyanosis (purple discoloration of the tissues and mucous membranes) without intercurrent pneumonia, it is advisable to look for methemoglobinemia. Methemoglobin is a brown pigment derived from hemoglobin, which is itself a red pigment contained in red blood cells and allows oxygen to be transported from the pulmonary alveoli to the tissues.
Methemoglobin is known to chemists and biologists as a trivalent iron, incapable of binding oxygen. Abnormal red blood cells contain about 1% methemoglobin. Methemoglobinemia is when red blood cells contain abnormally high amounts of methemoglobin.Drugs interactions
They are not described.