Definition
Definition
Fibrin stabilizing factor , also known as factor XIII, fibrinase, or transglutaminase, is a plasma protein produced by the liver that plays a role in blood clotting: it forms bonds between glutamine and lysine residues in proteins and stabilizes the fibrin polymers of the blood clot by forming bonds between their monomers. It is activated by thrombin.
Generalities
There are 12 coagulation factors, numbered from I to XIII (factor VI being identical to factor V). They are all essential:
Factor I: Fibrinogen
Factor II: Prothrombin
Factor III: Tissue thromboplastin
Factor IV: Calcium (Ca2+)
Factor V: Proaccelerin, Labile Factor A
Factor VI: Proaccelerin, Labile Factor A
Factor VII: Proconvertin, Serum prothrombin, Stable factor
Factor VIII: Antihemophilic Factor A, Thromboplastinogen
Factor IX: Antihemophilic factor B, Christmas factor
Factor X: Thrombokinase, Plasma thromboplastin, Stuart factor, Stuart-Prower factor
Factor XI: Antihemophilic factor C, Plasma prothromboplastic factor C
Factor XII: Hageman Factor, Activation Factor
Factor XIII : Fibrin Stabilizing Factor , Fibrinase , Transglutaminase
In blood coagulation, thrombin catalyzes the conversion of fibrin -stabilizing factor to its active form (fibrinase), leading to the formation of a stable clot. This process occurs through the activation of coagulation factors to form a blood clot that encloses red blood cells, white blood cells, and platelets within a fibrin molecular mesh , thus facilitating the definitive closure of a blood vessel.
Coagulation factors are proteins produced by the liver and participate in the formation of the blood clot when the coagulation process is activated.